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A-804598 (A804598)

This product is for research use only, not for human use. We do not sell to patients.

A-804598 (A804598)
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500mg$1250Check With Us
1g$1880Check With Us
email: [email protected]        [email protected]

Cat #: V0084 CAS #: 1125758-85-1 Purity ≥ 99%

Description: A-804598 (A 804598) is a structurally novel, CNS penetrant, potent, competitive, and selective antagonist of the purinergic P2X7 receptors (IC50 = 10 nM, 9 nM and 11 nM for rat, mouse and human P2X7 receptors respectively) with potential anti-inflammatory activity.

References: Paola Fabbrizio et al. P2X7 Receptor Activation Modulates Autophagy in SOD1-G93A Mouse Microglia.Cell Neurosci, 2017 Aug, 11:249.

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Molecular Weight (MW)315.38
Molecular FormulaC19H17N5
CAS No.1125758-85-1
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: > 10mg/mLrr
Water: N/Arr
Ethanol: N/A
SMILES CodeC[C@H](/N=C(NC1=C2C=CC=NC2=CC=C1)/NC#N)C3=CC=CC=C3
SynonymsA-804598; A 804598; A804598
ProtocolIn VivoA chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease
Animal modelAdult B6.Cg-Tg (SOD1-G93A) 1Gur/J female mice
Dosages30 mg/kg
AdministrationIntraperitoneal injection; five times a week
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.1708 mL15.8539 mL31.7078 mL63.4156 mL
5mM0.6342 mL3.1708 mL6.3416 mL12.6831 mL
10mM0.3171 mL1.5854 mL3.1708 mL6.3416 mL
20mM0.1585 mL0.7927 mL1.5854 mL3.1708 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.