CaMKII-IN-1 | CAS 1208123-85-6

CaMKII-IN-1

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
50mg	$1250	To Be Confirmed
100mg	$1850	To Be Confirmed
200mg	$2775	To Be Confirmed

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Cat #: V3429 CAS #: 1208123-85-6 Purity ≥ 98%

Description: CaMKII-IN-1, a 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine analog, is a novel, potent and highly selective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) inhibitor with IC50 of 63 nM.

References: Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	548.1
Molecular Formula	C29H30ClN5O2S
CAS No.	1208123-85-6
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=S(C1=CC=CC(Cl)=C1C)(NC2=C(CN(CC3=CC=CC=C3)CC4)C4=NC(NCCC5=CC=CC=C5)=N2)=O
Synonyms	CaMKII-IN 1; CaMKII IN-1; CaMKII IN 1; CaMKII-IN-1; CaMKII

Protocol	In Vitro	CaMKII-IN-1, a 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine analog, is a novel, potent and highly selective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) inhibitor with IC50 of 63 nM. In particular, the inhibitory activity of CaMKII-IN-1 was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, CaMKII-IN-1 exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8245 mL	9.1224 mL	18.2448 mL	36.4897 mL
5mM	0.3649 mL	1.8245 mL	3.6490 mL	7.2979 mL
10mM	0.1824 mL	0.9122 mL	1.8245 mL	3.6490 mL
20mM	0.0912 mL	0.4561 mL	0.9122 mL	1.8245 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.