Betahistine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $225 | Check With Us |
| 5g | $345 | Check With Us |
| 10g | $520 | Check With Us |
: Cat #: V8045 CAS #: 5638-76-6 Purity ≥ 98%
Description: Betahistine (also known as PT-9) is a potent histamine H3 receptor inhibitor with IC50 of 1.9 μM.
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- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 136.198 |
|---|---|
| Molecular Formula | C8H12N2 |
| CAS No. | 5638-76-6 |
| Protocol | In Vitro | Betahistine (0-10 μM) inhibits [125I]iodoproxyfan binding to membranes of CHO (rH3(445)R) and CHO (hH3(445)R) cells with IC50 values of 1.9 μM and 3.3 μM, respectively. Lead to Ki values of 1.4 μM and 2.5 μM, respectivel |
|---|---|---|
| In Vivo | Betahistine (intraperitoneal or oral administration; 0.1-30 mg/kg; single dose) with acute administration has increased tele-methylhistamine (t-MeHA) levels with an ED50 of 0.4 mg/kg, indicating the inverse agonism. Besides, after acute oral administration, it increases t-MeHA levels with an ED50 of 2 mg/kg in male Swissmice | |
| Animal model | Collagen-induced arthritis (CIA) DBA/1 male mouse model[3] | |
| Dosages | 1 mg/kg; 5mg/kg | |
| Administration | Oral adminstration; day 21 to day 42 after a 21-day CIA induction |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 7.3423 mL | 36.7113 mL | 73.4225 mL | 146.8450 mL |
| 5mM | 1.4685 mL | 7.3423 mL | 14.6845 mL | 29.3690 mL |
| 10mM | 0.7342 mL | 3.6711 mL | 7.3423 mL | 14.6845 mL |
| 20mM | 0.3671 mL | 1.8356 mL | 3.6711 mL | 7.3423 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.