Donepezil HCl (E2020)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $400 | Check With Us |
| 10g | $650 | Check With Us |
| 20g | $975 | Check With Us |
: Cat #: V1159 CAS #: 120011-70-3 Purity ≥ 98%
Description: Donepezil Hydrochloride (E2020; Aricept; E-2020), the hydrochloride salt of Donepezil, is a noncompetitive, specific and potent AChE inhibitor for bAChE and hAChE with antiAlzheimer's disease (AD) effects.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 416 |
|---|---|
| Molecular Formula | C24H29NO3.HCl |
| CAS No. | 120011-70-3 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLrr |
| Water: 5 mg/mL (12.01 mM)rr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 30mg/mL |
| Synonyms | E-2020; E2020; Aricept; E 2020; Donepezil HCl |
| Protocol | In Vitro | The neuroprotective mechanism of Donepezil Hydrochloride is associated with enhanced phosphorylation of Akt and GSK-3β, decreased phosphorylation of tau and glycogen synthetase |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4038 mL | 12.0192 mL | 24.0385 mL | 48.0769 mL |
| 5mM | 0.4808 mL | 2.4038 mL | 4.8077 mL | 9.6154 mL |
| 10mM | 0.2404 mL | 1.2019 mL | 2.4038 mL | 4.8077 mL |
| 20mM | 0.1202 mL | 0.6010 mL | 1.2019 mL | 2.4038 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.