Scopolamine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $295 | Check With Us |
| 2g | $450 | Check With Us |
| 5g | $690 | Check With Us |
: Cat #: V5514 CAS #: 51-34-3 Purity ≥ 99%
Description: Scopolamine (Hyoscine) is an approved medication used to treat motion sickness and postoperative nausea and vomiting.
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| Molecular Weight (MW) | 303.35 |
|---|---|
| Molecular Formula | C17H21NO4 |
| CAS No. | 51-34-3 |
| Synonyms | Scopolamine; Transderm SCOP; l-Scopolamine; SEE |
| Protocol | In Vitro | Scopolamine does not cause a response when applied alone to oocytes expressing the 5-HT3 receptor, but causes concentration-dependent response inhibition when co-applied with 2 μM 5-HT. Scopolamine has a pIC50 value of 5.68±0.05 (IC50=2.09 μM, n=6), Hill Slope of 1.06±0.05, and Kb of 3.23 μM. The same concentration-dependent effect can be seen when Scopolamine is applied during 5-HT application. To further test the competitive binding of 5-HT3 receptors, the competitiveness of unlabeled scopolamine was measured with [3H]granisetron, an established high-affinity competitive antagonist. Scopolamine competes with 0.6 nM [3H]granisetron (~Kd) with a mean pKi of 5.17±0.24 (Ki=6.76 μM, n=3) |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2965 mL | 16.4826 mL | 32.9652 mL | 65.9304 mL |
| 5mM | 0.6593 mL | 3.2965 mL | 6.5930 mL | 13.1861 mL |
| 10mM | 0.3297 mL | 1.6483 mL | 3.2965 mL | 6.5930 mL |
| 20mM | 0.1648 mL | 0.8241 mL | 1.6483 mL | 3.2965 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.