Diphemanil Methylsulfate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$320	In Stock
1g	$500	In Stock
5g	$1500	In Stock

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Cat #: V1195 CAS #: 62-97-5 Purity ≥ 98%

Description: Diphemanil methylsulfate (NSC 41725; NSC-41725; Prantal; Talpran; Diphemanil mesylate) is a quaternary ammonium anticholinergic agent used for a variety of conditions such as pylorospasm, peptic ulcer, gastric hyperacidity, hypermotility in gastritis, and hyperhidrosis.

References: Küng M, Diamond L. Effect of inhaled diphemanil methylsulfate, a parasympatholytic agent, on histamine induced bronchoconstriction in asymptomatic asthmatics. Ann Allergy. 1984 Jan;52(1):22-5.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	389.51
Molecular Formula	C20H24N.CH3O4S
CAS No.	62-97-5
Storage	-20℃ for 3 years in powder formrrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 25 mg/mL (64.2 mM)rrr
	Water: 28 mg/mL (71.9 mM)rrr
	Ethanol: <1 mg/mL
SMILES Code	[O-]S(=O(OC)=O.C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)\C3=CC=CC=C3
Synonyms	NSC41725; Diphemanil Methylsulfate; NSC 41725; NSC-41725; Prantal; Talpran; Chemical Name: 4-(diphenylmethylene)-1,1-dimethylpiperidin-1-ium methyl sulfate

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5673 mL	12.8366 mL	25.6733 mL	51.3466 mL
5mM	0.5135 mL	2.5673 mL	5.1347 mL	10.2693 mL
10mM	0.2567 mL	1.2837 mL	2.5673 mL	5.1347 mL
20mM	0.1284 mL	0.6418 mL	1.2837 mL	2.5673 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.