Galanthamine HBr

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$590	Check With Us
5g	$1050	Check With Us
10g	$1575	Check With Us

: [email protected] [email protected]

Cat #: V1204 CAS #: 1953-04-4 Purity ≥ 98%

Description: Galanthamine HBr (Razadyne, Reminyl), the hydrobromide salt of Galanthamine, is a centrally active and long-acting AChE/acetylcholinesterase inhibitor approved for the treatment of cognitive decline in Alzheimer's disease and various other memory impairments.

References: Debby Van Dam, et al. Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model. Psychopharmacology (Berl). 2005 Jun;180(1):177-90.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	368.27
Molecular Formula	C17H21NO3.HBr
CAS No.	1953-04-4
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: <1 mg/mLrr
	Water: 36 mg/mL (97.8 mM)rr
	Ethanol: <1 mg/mL
Solubility In Vivo	Saline: 20 mg/mL
Synonyms	Galantamine hydrobromide

Protocol	In Vivo	Galanthamine hydrobromide (1.25-2.5 mg/kg; i.p. ) reduces cognitive deficits in APP23 mice
	Animal model	APP23 mice
	Dosages	APP23 mice

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7154 mL	13.5770 mL	27.1540 mL	54.3080 mL
5mM	0.5431 mL	2.7154 mL	5.4308 mL	10.8616 mL
10mM	0.2715 mL	1.3577 mL	2.7154 mL	5.4308 mL
20mM	0.1358 mL	0.6788 mL	1.3577 mL	2.7154 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.