Rocuronium Bromide (ORG 9426 Bromide)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$280	Check With Us
1g	$420	Check With Us
5g	$630	Check With Us

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Cat #: V1176 CAS #: 119302-91-9 Purity ≥ 98%

Description: Rocuronium Bromide (ORG-9426; Zemuron; Esmeron; Esmeron; Esmerone) is a potent and competitive Nicotinic acetyl-choline receptors (AchR) antagonist, which is a non-depolarizing neuromuscular blocking agent used in anaesthesia required for surgery or mechanical ventilation.

References: Khuenl-Brady K, Castagnoli KP, Canfell PC, The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat. Anesthesiology. 1990 Apr;72(4):669-74.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	609.68
Molecular Formula	C32H53N2O4.Br
CAS No.	119302-91-9
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 122 mg/mL (200.1 mM)rr
	Water: 122 mg/mL (200.1 mM)rr
	Ethanol: 122 mg/mL (200.1 mM)
SMILES Code	CC(=O)OC1C(CC2C1(CCC3C2CCC4C3(CC(C(C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]
Synonyms	ORG9426; Rocuronium Bromide; Zemuron; Rocuronium (Bromide); ORG 9426 ;ORG-9426; Esmeron; UNII-I65MW4OFHZ; Esmeron; Esmerone;

Protocol	In Vivo	Only 8.7±5.7% (SD) and 6.0±2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4±9.2% and 52.4±9.2% of an injected dose of ORG 9426 and 35.7±12.2% and 46.8±9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.6402 mL	8.2010 mL	16.4020 mL	32.8041 mL
5mM	0.3280 mL	1.6402 mL	3.2804 mL	6.5608 mL
10mM	0.1640 mL	0.8201 mL	1.6402 mL	3.2804 mL
20mM	0.0820 mL	0.4101 mL	0.8201 mL	1.6402 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.