PNU-120596 (NSC-216666)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $980 | Check With Us |
| 1g | $1470 | Check With Us |
: Cat #: V1191 CAS #: 501925-31-1 Purity ≥ 98%
Description: PNU-120596 (PNU120596; NSC 216666; PNU 120596; NSC-216666) is a potent and selective PAM (positive allosteric modulator) of α7 nAChR (acetylcholine receptor) with an EC50 of 216 NM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 311.72 |
|---|---|
| Molecular Formula | C13H14ClN3O4 |
| CAS No. | 501925-31-1 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 62 mg/mL (198.9 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 10 mg/mL |
| SMILES Code | O=C(NC1=NOC(C)=C1)NC2=CC(Cl)=C(OC)C=C2OC |
| Synonyms | PNU-120596; NSC 216666; PNU 120596; NSC-216666; PNU120596;NSC216666 |
| Protocol | In Vitro | PNU-120596 increases agonist-evoked calcium flux mediated by an engineered variant of the human α7 nAChR. Electrophysiology studies confirme that PNU-120596 increases peak agonist-evoked currents mediated by wild-type receptors and also demonstrates a pronounced prolongation of the evoked response in the continued presence of agonist. PNU-120596 increases the channel mean open time of α7 nAChRs |
|---|---|---|
| In Vivo | PNU-120596 (1 mg/kg; intravenous injection; once) treatment improves the auditory gating deficit caused by Amphetamine in rats, a model proposed to reflect a circuit level disturbance associated with schizophrenia | |
| Animal model | Male Sprague Dawley rats (250-300 g) treated with Amphetamine |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2080 mL | 16.0400 mL | 32.0801 mL | 64.1601 mL |
| 5mM | 0.6416 mL | 3.2080 mL | 6.4160 mL | 12.8320 mL |
| 10mM | 0.3208 mL | 1.6040 mL | 3.2080 mL | 6.4160 mL |
| 20mM | 0.1604 mL | 0.8020 mL | 1.6040 mL | 3.2080 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.