Diphenidol HCl (Difenidol)

This product is for research use only, not for human use. We do not sell to patients.

Diphenidol HCl (Difenidol)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
25g$350Check With Us
50g$550Check With Us
100g$825Check With Us

Cat #: V1167 CAS #: 3254-89-5 Purity ≥ 98%

Description: Diphenidol HCl (Vontrol; Difenidol), the hydrochloride salt of diphenidol which is an antiemetic, is a potent antagonist of muscarinic M2 and M3 receptors used as an antiemetic and as an antivertigo agent.

References: Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.

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Molecular Weight (MW)345.91
Molecular FormulaC21H28ClNO
CAS No.3254-89-5
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 69 mg/mL (199.5 mM)rr
Water: 13 mg/mL (37.6 mM)rr
Ethanol: 36 mg/mL (104.1 mM)
SMILES CodeOC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.[H]Cl
SynonymsDifenidol hydrochloride
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.8909 mL14.4546 mL28.9093 mL57.8185 mL
5mM0.5782 mL2.8909 mL5.7819 mL11.5637 mL
10mM0.2891 mL1.4455 mL2.8909 mL5.7819 mL
20mM0.1445 mL0.7227 mL1.4455 mL2.8909 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.