Paroxetine HCl (BRL29060）
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $400 | Check With Us |
| 5g | $650 | Check With Us |
| 10g | $975 | Check With Us |
: Cat #: V1164 CAS #: 78246-49-8 Purity ≥ 98%
Description: Paroxetine HCl (formerly BRL-29060A, BRL29060A, FG7051; FG-7051), the hydrochloride salt of Paroxetine, is a potent and selective serotonin uptake inhibitor (SSRI) that is effective in the treatment of depression.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 365.83 |
|---|---|
| Molecular Formula | C19H20FNO3.HCl |
| CAS No. | 78246-49-8 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 73 mg/mL (199.5 mM)rr |
| Water: 10 mg/mL (27.3 mM)rr | |
| Ethanol: 35 mg/mL (95.7 mM) | |
| SMILES Code | FC1=CC=C([C@H]2[C@H](COC3=CC=C(OCO4)C4=C3)CNCC2)C=C1.[H]Cl |
| Synonyms | BRL-29060A, BRL29060A, FG7051; FG 7051; Paroxetine HCl; Paroxetine Hydrochloride; BRL 29060A, FG-7051; BRL29060 hydrochloride; BRL29060A; BRL 29060; BRL-29060 |
| Protocol | In Vitro | Paroxetine (1 μM and 10 μM) significantly inhibited CX2CL3-induced T cell migration by inhibiting GRK1. Paroxetine inhibits GRK2-induced ERK activation |
|---|---|---|
| In Vivo | Paroxetine hydrochloride treatment significantly reduced symptoms in CIA rats. Paroxetine hydrochloride treatment significantly prevented tissue damage to the joint and reduced the infiltration of T cells into synovial tissue. Paroxetine hydrochloride shows a strong effect on inhibiting CX3CL1 production in synovial tissue |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7335 mL | 13.6676 mL | 27.3351 mL | 54.6702 mL |
| 5mM | 0.5467 mL | 2.7335 mL | 5.4670 mL | 10.9340 mL |
| 10mM | 0.2734 mL | 1.3668 mL | 2.7335 mL | 5.4670 mL |
| 20mM | 0.1367 mL | 0.6834 mL | 1.3668 mL | 2.7335 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.