Pancuronium dibromide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $600 | Check With Us |
| 1g | $950 | Check With Us |
| 5g | $1425 | Check With Us |
: Cat #: V1162 CAS #: 15500-66-0 Purity ≥ 98%
Description: Pancuronium dibromide (OrgNA97; NA-97; Org NA 97; Pavulon), a neuromuscular relaxant used in euthanasia, is a bis-quaternary steroid and a competitive nicotinic acetylcholine receptor antagonist with an IC50 of 5.5 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 732.67 |
|---|---|
| Molecular Formula | C35H60N2O4.2Br |
| CAS No. | 15500-66-0 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (136.5 mM)rr |
| Water:100 mg/mL (136.5 mM)rr | |
| Ethanol: 100 mg/mL (136.5 mM) | |
| SMILES Code | C[C@@]12[C@@H](OC(C)=O)[C@@H]([N+]3(C)CCCCC3)C[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H]([N+]6(C)CCCCC6)C[C@]5(C)[C@@]4([H])CC2.[Br-].[Br-] |
| Synonyms | NA-97; Org-NA-97; NA97; OrgNA97; NA 97; Org NA 97; Pavulon |
| Protocol | In Vitro | The action of Pancuronium on transmembrane sodium conductance is investigated in dorsal root ganglion neurones of chick embryos. Externally perfused Pancuronium (50 μM to 1 mM) reversibly inhibits the current by a fast mechanism of action. Inhibition is concentration-dependent (with a half-effective dose of 170 μM) but not voltage-dependent. Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3649 mL | 6.8244 mL | 13.6487 mL | 27.2974 mL |
| 5mM | 0.2730 mL | 1.3649 mL | 2.7297 mL | 5.4595 mL |
| 10mM | 0.1365 mL | 0.6824 mL | 1.3649 mL | 2.7297 mL |
| 20mM | 0.0682 mL | 0.3412 mL | 0.6824 mL | 1.3649 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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C1
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V1
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C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.