(-)-Dizocilpine Maleate [(-)-MK 801 maleate]

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$900	Check With Us
1g	$1550	Check With Us
5g	$4600	Check With Us

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Cat #: V1081 CAS #: 121917-57-5 Purity ≥ 98%

Description: (-)-Dizocilpine Maleate [also known as (-)-MK-801; MK801; MK 801], the maleate salt of dizocilpine, is a novel, potent, selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potential to treat a wide range of neurodegenerative conditions or disorders in which NMDA receptors play an important role.

References: Yang B, et al. Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model. Int J Neuropsychopharmacol. 2016 Dec 30;19(12).

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	337.37
Molecular Formula	C20H19NO4
CAS No.	121917-57-5
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 67 mg/mL (198.6 mM)rr
	Water: <1 mg/mLrr
	Ethanol: 7 mg/mL (20.7 mM)
Solubility In Vivo	30% PEG400+0.5% Tween80+5% propylene glycol: 15 mg/mL
Synonyms	MK801; MK 801; Dizocilpine; MK-801; MK 801 Maleate

Protocol	In Vivo	(-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model
	Animal model	Male adult C57BL/6 mice ( 20-25g; aged 8 weeks) with social defeat stress model
	Dosages	0.1 mg/kg
	Administration	Intraperitoneal injection

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9641 mL	14.8205 mL	29.6410 mL	59.2821 mL
5mM	0.5928 mL	2.9641 mL	5.9282 mL	11.8564 mL
10mM	0.2964 mL	1.4821 mL	2.9641 mL	5.9282 mL
20mM	0.1482 mL	0.7410 mL	1.4821 mL	2.9641 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.