AP-5
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1750 | Check With Us |
| 1g | $2800 | Check With Us |
| 5g | $8400 | Check With Us |
: Cat #: V11432 CAS #: 76326-31-3 Purity ≥ 98%
Description: AP-5 (AP5) is a novel, selective and potent NMDA (N-methyl-D-aspartate) receptor antagonist with anticonvulsant activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 197.13 |
|---|---|
| Molecular Formula | C5H12NO5P |
| CAS No. | 76326-31-3 |
| Protocol | In Vitro | DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels |
|---|---|---|
| In Vivo | DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA | |
| Animal model | Male Wistar rats (180-230 g) | |
| Dosages | 1, 3.2 and 10 μg/rat | |
| Administration | Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.0728 mL | 25.3640 mL | 50.7279 mL | 101.4559 mL |
| 5mM | 1.0146 mL | 5.0728 mL | 10.1456 mL | 20.2912 mL |
| 10mM | 0.5073 mL | 2.5364 mL | 5.0728 mL | 10.1456 mL |
| 20mM | 0.2536 mL | 1.2682 mL | 2.5364 mL | 5.0728 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.