NMDA (N-Methyl-D-aspartic acid)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $340 | Check With Us |
| 2g | $590 | Check With Us |
| 5g | $950 | Check With Us |
: Cat #: V1086 CAS #: 6384-92-5 Purity ≥ 98%
Description: NMDA (N-Methyl-D-aspartic acid; LC488A; LC488 A; LC488-A; LC 488A; LC-488A) is an aspartic acid analog with an N-methyl substituent and D-configuration and a glutamate-like excitatory chemical substance.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 147.13 |
|---|---|
| Molecular Formula | C5H9NO4 |
| CAS No. | 6384-92-5 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 5 mg/mL (33.98 mM)rr |
| Water: 30 mg/mL (203.9 mM)rr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Chemical Name: N-Methyl-D-aspartic acid InChi Key: RVHOBHMAPRVOLO-SCSAIBSYSA-N InChi Code: InChI=1S/C6H10O4/c1-2-4(6(9)10)3-5(7)8/h4H,2-3H2,1H3,(H,7,8)(H,9,10)/t4-/m1/s1 |
| SMILES Code | O=C(O)C[C@H](C(O)=O)CC |
| Synonyms | LC488A; LC488 A; LC488-A; LC 488A; LC-488A |
| Protocol | In Vivo | NMDA (0.2 nM) showed significant effects on MF, IF, IL, and EL, respectively, reducing insertion and insertion frequency, and reducing insertion and ejaculation delays. NMDA and AP-5 significantly promoted and inhibited ejaculation behavior during the 30 min of the mating test, respectively. Bilateral microinjection of NMDA to PVN significantly increases baseline LSNA, and the peak LSNA increment occurs within 5 minutes of PVN microinjection NMDA |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 6.7967 mL | 33.9836 mL | 67.9671 mL | 135.9342 mL |
| 5mM | 1.3593 mL | 6.7967 mL | 13.5934 mL | 27.1868 mL |
| 10mM | 0.6797 mL | 3.3984 mL | 6.7967 mL | 13.5934 mL |
| 20mM | 0.3398 mL | 1.6992 mL | 3.3984 mL | 6.7967 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.