Lornoxicam (Chlortenoxicam; Ro 13-9297; TS110)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$650	Check With Us
10g	$950	Check With Us
20g	$1425	Check With Us

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Cat #: V1066 CAS #: 70374-39-9 Purity ≥ 98%

Description: Lornoxicam (Chlortenoxicam; Xefo; Lornoxicamum; Xefocam; TS-110; Ro 13-9297; TS110), a non-steroidal anti-inflammatory drug (NSAID), is a potent COX-1/COX-2 inhibitor with potential anti-inflammatory activity.

References: Spyra S, et al. COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2017 Aug;174(16):2696-2705.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	371.82
Molecular Formula	C13H10ClN3O4S2
CAS No.	70374-39-9
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 3 mg/mL (8.1 mM)rr
	Water: <1 mg/mLrr
	Ethanol: <1 mg/mL
Solubility In Vivo	Chemical Name: 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide InChi Key: WLHQHAUOOXYABV-UHFFFAOYSA-N InChi Code: InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19) SMILES Code: CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
SMILES Code	CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
Synonyms	Ro 13-9297; TS 110; Ro-13-9297; TS-110; Ro13-9297; TS110; Chlortenoxicam; Lornoxicam; Chlortenoxicam; Xefo; Lornoxicamum; Xefocam; xefocam

Protocol	In Vivo

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6895 mL	13.4474 mL	26.8947 mL	53.7895 mL
5mM	0.5379 mL	2.6895 mL	5.3789 mL	10.7579 mL
10mM	0.2689 mL	1.3447 mL	2.6895 mL	5.3789 mL
20mM	0.1345 mL	0.6724 mL	1.3447 mL	2.6895 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.