LQZ 7I
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1100 | To Be Confirmed |
| 500mg | $1650 | To Be Confirmed |
| 1g | $2475 | To Be Confirmed |
: Cat #: V2178 CAS #: 195822-23-2 Purity ≥ 98%
Description: LQZ-7I is a novel malarial protease PfSUB1 inhibitor.
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| Molecular Weight (MW) | 348.35 |
|---|---|
| Molecular Formula | C20H14F2N4 |
| CAS No. | 195822-23-2 |
| SMILES Code | O=C1N(C2=CC=CC=C2OC)C(/C=C/C3=CC=C(O)C(O)=C3)=NC4=C1C=CC=C4 |
| Synonyms | ICCB-280; ICCB280; ICCB 280; |
| Protocol | In Vitro | LQZ-7I (10 µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin. LQZ-7I has improved cytotoxicity with IC50s of 3.1 µM against C4-2 cells and 4.8 µM against PC-3 cells compared with the parent compound LQZ-7. |
|---|---|---|
| In Vivo | LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8707 mL | 14.3534 mL | 28.7068 mL | 57.4135 mL |
| 5mM | 0.5741 mL | 2.8707 mL | 5.7414 mL | 11.4827 mL |
| 10mM | 0.2871 mL | 1.4353 mL | 2.8707 mL | 5.7414 mL |
| 20mM | 0.1435 mL | 0.7177 mL | 1.4353 mL | 2.8707 mL |
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Step One: Enter information below
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Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.