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PROTAC PD-1/PD-L1 degrader-1

This product is for research use only, not for human use. We do not sell to patients.

PROTAC PD-1/PD-L1 degrader-1
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$39751 Month
200mg$59601 Month
500mg$10551 Month
email: [email protected]        [email protected]

Cat #: V34656 CAS #: 2447066-37-5 Purity ≥ 99%

Description: PROTAC PD-1/PD-L1 degrader-1 is a novel First-in-class PD-L1 degrader based on PROTAC technology.

References: Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.

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Molecular Weight (MW)1076.59
Molecular FormulaC59H58ClN7O11
CAS No.2447066-37-5
SMILES CodeO=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCC(N4CCN(C(C5N(CC6=CC(Cl)=C(OCC7=CC=CC(C8=CC=C9OCCOC9=C8)=C7C)C=C6OCC%10=CC=CC(C#N)=C%10)CCCC5)=O)CC4)=O
SynonymsCUN-01077; CUN01077; CUN 01077; PD-L1 degrader P22;
ProtocolIn VitroPROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively.
In VivoPROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM0.9289 mL4.6443 mL9.2886 mL18.5772 mL
5mM0.1858 mL0.9289 mL1.8577 mL3.7154 mL
10mM0.0929 mL0.4644 mL0.9289 mL1.8577 mL
20mM0.0464 mL0.2322 mL0.4644 mL0.9289 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.