HDM201 (Siremadlin) HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$900	Check With Us
250mg	$1650	Check With Us
500mg	$2475	Check With Us

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Cat #: V3166 CAS #: 1448867-41-1 (free base) Purity ≥ 98%

Description: HDM201 HCl (also called Siremadlin; NVP-HDM201, HDM stands for 'human double minute 2 homolog') is an orally bioavailable, highly potent and selective inhibitor of the p53-Mdm2 protein-protein interaction.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	555.41
Molecular Formula	C26H24Cl2N6O4
CAS No.	1448867-41-1 (free base)
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ~100 mg/mL (180.0 mM)r
	Water: < 1 mg/mLr
	Ethanol: 3 mg/mL (5.4 mM)
SMILES Code	O=C1N(C2=CC(Cl)=CN(C)C2=O)[C@@H](C3=CC=C(Cl)C=C3)C4=C1N=C(C5=CN=C(OC)N=C5OC)N4C (C)C
Synonyms	HDM-201; HDM 201; HDM201; NVP-HDM 201; NVP-HDM201; NVP-HDM-201

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8005 mL	9.0024 mL	18.0047 mL	36.0094 mL
5mM	0.3601 mL	1.8005 mL	3.6009 mL	7.2019 mL
10mM	0.1800 mL	0.9002 mL	1.8005 mL	3.6009 mL
20mM	0.0900 mL	0.4501 mL	0.9002 mL	1.8005 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.