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BAI1 (Bax channel blocker)

This product is for research use only, not for human use. We do not sell to patients.

BAI1 (Bax channel blocker)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1300Check With Us
500mg$2050Check With Us
1g$3075Check With Us
email: [email protected]        [email protected]

Cat #: V5240 CAS #: 335165-68-9 Purity ≥ 98%

Description: BAI1 is a novel, potent and direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM.

References: Garner TP, et al. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol. 2019 Apr;15(4):322-330.

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Molecular Weight (MW)467.20
Molecular FormulaC19H21Br2N3O
CAS No.335165-68-9
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeOC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3
SynonymsBrain-specific angiogenesis inhibitor 1; BAI1; BAI 1; BAI-1
ProtocolIn VitroBAI1 shows inhibition of tBID (HY-100464)-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC50 of 3.3 μΜ. BAI1 selectively inhibits BAX-mediated apoptotic cell death.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1404 mL10.7021 mL21.4041 mL42.8082 mL
5mM0.4281 mL2.1404 mL4.2808 mL8.5616 mL
10mM0.2140 mL1.0702 mL2.1404 mL4.2808 mL
20mM0.1070 mL0.5351 mL1.0702 mL2.1404 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.