WEHI-539 hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1500 | Check With Us |
| 500mg | $2300 | Check With Us |
| 1g | $3450 | Check With Us |
: Cat #: V2772 CAS #: 2070018-33-4 Purity ≥ 98%
Description: WEHI-539 hydrochloride, the HCl salt of WEHI-539, is a potent and selective inhibitor of BCL-XL with IC50 value of 1.1 nM.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 620.18 |
|---|---|
| Molecular Formula | C31H29N5O3S2.HCl |
| CAS No. | 2070018-33-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (161.2 mM)r |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(C1=C(CCCOC2=CC=C(CN)C=C2)SC(C(C=C/34)=CC=C4CCCC3=N/NC5=NC6=CC=CC=C6S5)=N1)O.[H]Cl |
| Synonyms | WEHI539 hydrochloride; WEHI-539; WEHI 539 HCl |
| Protocol | In Vitro | WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL. WEHI-539 augments NSC 241240 induced caspase 3/7 activity, PARP cleavage and annexin V labelling. WEHI-539 as a single agent causes noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6124 mL | 8.0622 mL | 16.1244 mL | 32.2487 mL |
| 5mM | 0.3225 mL | 1.6124 mL | 3.2249 mL | 6.4497 mL |
| 10mM | 0.1612 mL | 0.8062 mL | 1.6124 mL | 3.2249 mL |
| 20mM | 0.0806 mL | 0.4031 mL | 0.8062 mL | 1.6124 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.