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| Size | Price | Stock |
|---|---|---|
| 10mg | $200 | 3-6 Days |
| 25mg | $400 | 3-6 Days |
| 50mg | $700 | 3-6 Days |
| 100mg | $1250 | 3-6 Days |
: Cat #: V10535 CAS #: 1638178-82-1 Purity ≥ 98%
Description: TIC10 (imipridone, ONC-201) HCl is a novel, potent, orally bioactive, brain penetrant, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. TIC10 can inactivate Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. TIC10 is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10.
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| Molecular Formula | C24H28Cl2N4O |
|---|---|
| CAS No. | 1638178-82-1 |
| SMILES Code | O=C1N(CC2=CC=CC=C2C)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4.[H]Cl.[H]Cl |
| Synonyms | ONC-201 Dihydrochloride, ONC-201 HCl, ONC201; ONC 201; ONC-201; NSC350625; NSC-350625; NSC 350625; imipridone; TIC10; TIC 10; TIC-10 |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.