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| Size | Price | Stock |
|---|---|---|
| 1g | $99999 | Not In Stock |
: Cat #: V8144 CAS #: 630100-90-2 Purity ≥ 98%
Description: E7107 (E-7107), a semisynthetic pladienolide B derivative, is a first-in-class and potent precursor messenger ribonucleic acid (pre-mRNA) spliceosome inhibitor that targets the Splicing factor 3B subunit 1 (SF3b1) of the spliceosome, and shows significant antitumor activities. It is a semisynthetic derivative of the natural product pladienolide B which was originally isolated from Streptomyces platensis. Development of E7107 was suspended after Phase I clinical trials due to an unacceptable profile of adverse events.
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| Molecular Weight (MW) | 718.97 |
|---|---|
| Molecular Formula | C40H66N2O9 |
| CAS No. | 630100-90-2 |
| Synonyms | E-7107; E7107; E 7107 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.3909 mL | 6.9544 mL | 13.9088 mL | 27.8176 mL |
| 5mM | 0.2782 mL | 1.3909 mL | 2.7818 mL | 5.5635 mL |
| 10mM | 0.1391 mL | 0.6954 mL | 1.3909 mL | 2.7818 mL |
| 20mM | 0.0695 mL | 0.3477 mL | 0.6954 mL | 1.3909 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.