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GLPG0259

This product is for research use only, not for human use. We do not sell to patients.

GLPG0259
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10mg$180To Be Confirmed
25mg$360To Be Confirmed
50mg$600To Be Confirmed
100mg$1050To Be Confirmed
email: [email protected]        [email protected]

Cat #: V27318 CAS #: 959754-85-9 Purity ≥ 99%

Description: GLPG-0259 (GLPG0259) is a novel, potent and selective small-molecule inhibitor of mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5) with the potential for the treatment of rheumatoid arthritis. MAPKAPK5 is a kinase that plays an important role in inflammatory pathways. It is a key regulator of cytokine production, and is therefore a potential target for treatment of rheumatoid arthritis (RA).

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Molecular FormulaC24H28N8O2
CAS No.959754-85-9
SMILES CodeO=C(C1=CC(C2=CN=C(NC3=CC=C(N4CCN(C(C)(C)C)CC4)C=C3)C5=NC=NN52)=CO1)N 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.