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Latanoprostene (PF-3187207)

This product is for research use only, not for human use. We do not sell to patients.

Latanoprostene (PF-3187207)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$1503-6 Days
10mg$2503-6 Days
25mg$4503-6 Days
50mg$7503-6 Days
100mg$12503-6 Days
250mg$21503-6 Days
email: [email protected]        [email protected]

Cat #: V6047 CAS #: 860005-21-6 Purity ≥ 99%

Description: Latanoprostene (PF3187207; Latanoprostene BUNOD; LBN; BOL-303259-X; NCX116; Vesneo; Vyzulta) is a novel and potent nitric oxide (NO)-donating FP receptor (Prostaglandin F2α receptor) agonist with prostaglandin activity. It loweres intraocular pressure (IOP) more effectively than latanoprost in monkeys, dogs and rabbits. Latanoprostene was approved for use as an ophthalmic drug in the United States in 2017 for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It targets the trabecular meshwork directly.

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Molecular Weight (MW)507.62
Molecular FormulaC27H41NO8
CAS No.860005-21-6
SMILES CodeO=C(OCCCCO[N+]([O-])=O)CCC/C=CC[C@@H]1[C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O 
Synonyms PF-3187207; NCX116; PF3187207; NCX-116; PF 3187207; Latanoprostene BUNOD; BOL-303259-X; NCX116; Vesneo; Vyzulta
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.9700 mL9.8499 mL19.6998 mL39.3996 mL
5mM0.3940 mL1.9700 mL3.9400 mL7.8799 mL
10mM0.1970 mL0.9850 mL1.9700 mL3.9400 mL
20mM0.0985 mL0.4925 mL0.9850 mL1.9700 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.