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Rac-Nedisertib

This product is for research use only, not for human use. We do not sell to patients.

Rac-Nedisertib
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1mg$999999Discontined
email: [email protected]        [email protected]

Cat #: V32429 CAS #: 1637542-34-7 Purity ≥ 99%

Description: This product is discontinued due to commercial reason. Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib. Nedisertib (M-3814, MSC-2490484A) is a poten, selective and orally bioavailable inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 of<3 nM and with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, the DNA-PK inhibitor MSC2490484A binds to and inhibits the activity of DNA-PK. This inhibits the ability of tumor cells to repair damaged DNA, which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK.

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Molecular FormulaC₂₄H₂₁ClFN₅O₃
CAS No.1637542-34-7
SMILES CodeCOC1=NN=C(C(O)C2=C(Cl)C=C(F)C(C3=C4C(C=C(N5CCOCC5)C=C4)=NC=N3)=C2)C=C1           
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.