RN1734 | CAS 946387-07-1

RN1734

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
25mg	$150	To Be Confirmed
50mg	$250	To Be Confirmed
100mg	$450	To Be Confirmed
250mg	$850	To Be Confirmed

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Cat #: V8798 CAS #: 946387-07-1 Purity ≥ 99%

Description: RN-1734 (RN1734) is a novel and potent TRPV4 antagonist, acting by completely blocking 4αPDD-mediated activation of TRPV4 with micromolar IC50s for three species (IC50 = 2.3 μM, 5.9 μM, 3.2 μM for hTRPV4, mTRPV4 ,rTRPV4, respectively).

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Molecular Weight (MW)	353.3
Molecular Formula	C14H22Cl2N2O2S
CAS No.	946387-07-1
SMILES Code	O=S(C1=CC=C(Cl)C=C1Cl)(N(C(C)C)CCNC(C)C)=O
Synonyms	RN-1734; RN 1734

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8305 mL	14.1523 mL	28.3046 mL	56.6091 mL
5mM	0.5661 mL	2.8305 mL	5.6609 mL	11.3218 mL
10mM	0.2830 mL	1.4152 mL	2.8305 mL	5.6609 mL
20mM	0.1415 mL	0.7076 mL	1.4152 mL	2.8305 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.