VU0467154 | CAS 1451993-15-9

VU0467154

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10mg	$150	To Be Confirmed
25mg	$250	To Be Confirmed
50mg	$400	To Be Confirmed
100mg	$700	To Be Confirmed
250mg	$1400	To Be Confirmed

: [email protected] [email protected]

Cat #: V28101 CAS #: 1451993-15-9 Purity ≥ 99%

Description: VU0467154 (VU-0467154) is a novel and potent M4 PAM (positive allosteric modulator) with the potential to be used as a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. Acting on muscarinic acetylcholine receptor (mAChR). VU0467154 exhibits robust APD-like and cognitive enhancing activity in rodents. Selective M4 PAMs could provide a therapeutic strategy for the treatment of HD.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	444.4472
Molecular Formula	C17H15F3N4O3S2
CAS No.	1451993-15-9
Synonyms	VU0467154, VU-0467154, VU 0467154

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2500 mL	11.2499 mL	22.4999 mL	44.9997 mL
5mM	0.4500 mL	2.2500 mL	4.5000 mL	8.9999 mL
10mM	0.2250 mL	1.1250 mL	2.2500 mL	4.5000 mL
20mM	0.1125 mL	0.5625 mL	1.1250 mL	2.2500 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.