PD-1/PD-L1-IN-18

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V45895 CAS #: 2648851-27-6 Purity ≥ 99%

Description: PD-1/PD-L1-IN-18 is a novel small molecule inhibitor of the PD-1/PD-L1 protein-protein interaction (IC50 of = 1.054 μM) with anticancer and immunomodulatory/immunoregulatory activity.

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Stock Solution Preparation
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Molecular Weight (MW)	685.43
Molecular Formula	C33H32BrCl2N3O4
CAS No.	2648851-27-6

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.4589 mL	7.2947 mL	14.5894 mL	29.1788 mL
5mM	0.2918 mL	1.4589 mL	2.9179 mL	5.8358 mL
10mM	0.1459 mL	0.7295 mL	1.4589 mL	2.9179 mL
20mM	0.0729 mL	0.3647 mL	0.7295 mL	1.4589 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.