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PD-1/PD-L1-IN-24

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PD-1/PD-L1-IN-24
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email: [email protected]        [email protected]

Cat #: V49277 CAS #: 2667680-33-1 Purity ≥ 99%

Description: PD-1/PD-L1-IN-24 is a novel small molecule inhibitor of the PD-1/PD-L1 protein-protein interaction (IC50 of = 1.6 nM) with anticancer and immunomodulatory/immunoregulatory activity.

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Molecular Weight (MW)640.08
Molecular FormulaC34H30ClN5O6
CAS No.2667680-33-1
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.5623 mL7.8115 mL15.6230 mL31.2461 mL
5mM0.3125 mL1.5623 mL3.1246 mL6.2492 mL
10mM0.1562 mL0.7812 mL1.5623 mL3.1246 mL
20mM0.0781 mL0.3906 mL0.7812 mL1.5623 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.