This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 1mg | $500 | 3-6 Days |
| 2mg | $850 | 3-6 Days |
| 5mg | $1350 | 3-6 Days |
| 10mg | $1950 | 3-6 Days |
: Cat #: V41588 CAS #: NA Purity ≥ 99%
Description: Compound 6q is a novel and potent steroidal anti-inflammatory agent that has the potential to be used in the treatment of IBD (inflammatory bowel diseases). Compound 6q effectively inhibited the production of nitric oxide (NO) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages. It also inhibited the expression of inducible NO synthase (iNOS) and prostaglandin synthase-2 (COX-2) at mRNA level. Compound 6q displayed inhibitory effects on both iNOS and COX-2 expression in a concentration-dependent manner. Furthermore, 6q was found to effectively decrease the mRNA and protein levels of interleukin 6 (IL-6). Mechanically, 6q could potently downregulate NF-κB signaling via suppression of the Akt/PI3K pathway. Moreover, 6q demonstrated high in vivo anti-inflammatory activities in a mouse colitis model induced by dextran sulfate sodium (DSS). Taken together, these data indicate that 6q represents a novel and promising anti-inflammatory bowel diseases (IBD) agent worthy of further investigation.
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| Molecular Weight (MW) | 366.51 |
|---|---|
| CAS No. | NA |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7284 mL | 13.6422 mL | 27.2844 mL | 54.5688 mL |
| 5mM | 0.5457 mL | 2.7284 mL | 5.4569 mL | 10.9138 mL |
| 10mM | 0.2728 mL | 1.3642 mL | 2.7284 mL | 5.4569 mL |
| 20mM | 0.1364 mL | 0.6821 mL | 1.3642 mL | 2.7284 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.