SHMT-IN-2 | CAS 2102681-49-0

SHMT-IN-2

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5mg	$150	3-6 Days
10mg	$250	3-6 Days
25mg	$450	3-6 Days
50mg	$750	3-6 Days
100mg	$1200	3-6 Days

: [email protected] [email protected]

Cat #: V44337 CAS #: 2102681-49-0 Purity ≥ 99%

Description: SHMT-IN-2 is an inhibitor of human SHMT1/2 which is a serine hydroxymethyltransferase (SHMT). It has anticancer activity by inhibiting SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	431.45
Molecular Formula	C22H24F3N5O
CAS No.	2102681-49-0
Synonyms	SHMT-IN-2; Serine hydroxymethyltranferase inhibitor 2; SHIN-2; SHIN2; SHIN 2

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3178 mL	11.5888 mL	23.1777 mL	46.3553 mL
5mM	0.4636 mL	2.3178 mL	4.6355 mL	9.2711 mL
10mM	0.2318 mL	1.1589 mL	2.3178 mL	4.6355 mL
20mM	0.1159 mL	0.5794 mL	1.1589 mL	2.3178 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.