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NVP-DKY709

This product is for research use only, not for human use. We do not sell to patients.

NVP-DKY709
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$2003-6 Days
10mg$3503-6 Days
25mg$6503-6 Days
50mg$10503-6 Days
email: [email protected]        [email protected]

Cat #: V42057 CAS #: 2291360-73-9 Purity ≥ 99%

Description: NVP-DKY709 (NVP-DKY-709; DKY-709) is a first-in-class selective cereblon (CRBN) glue degrader of IKZF2 with anticancer and may be used for cancer immunotherapy. It spares IKZF1 and IKZF3 from degradation. X-ray crystal structure of IKZF2 zinc fingers bound to DDB1:CRBN:NVP-DKY709 explained the target selectivity of NVP-DKY709. In vitro, NVP-DKY709 modulated Treg cell and Teff cell functions. In a mouse breast cancer xenograft model, daily oral dosing with NVP-DKY709 led to degradation of IKZF2 in tumour and peripheral blood Treg cells, reducing tumour growth similarly to that achieved with the anti-PD1 antibody PDR001. Oral NVP-DKY709 effectively degraded IKZF2 in monkeys and patients and is currently being evaluated in a first-in-human phase I trial in solid tumours.

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Molecular FormulaC25H27N3O3
CAS No.2291360-73-9
SMILES Code O=C1C2=CC=C(C=C2CN1C1CCC(=O)NC1=O)C1CCN(CC2C=CC=CC=2)CC1
Synonyms NVP-DKY709; DKY-709; NVP-DKY-709; DKY 709;NVP-DKY 709; DKY709
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.