Emixustat (ACU-4429)
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 5mg | $165 | 3-6 Days |
| 10mg | $280 | 3-6 Days |
| 25mg | $550 | 3-6 Days |
| 50mg | $900 | 3-6 Days |
: Cat #: V33778 CAS #: 1141777-14-1 Purity ≥ 99%
Description: Emixustat (ACU4429) is a novel and potent inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro.
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| Molecular Weight (MW) | 263.38 |
|---|---|
| Molecular Formula | C₁₆H₂₅NO₂ |
| CAS No. | 1141777-14-1 |
| Synonyms | ACU-4429 |
| Protocol | In Vitro | Emixustat (ACU-4429) potently inhibits isomerase activity in vitro (IC50=4.4 nM). Treatment of emixustat shows a concentration dependent reduction of 11-cis-ROL production [1]. Emixustat strongly inhibits 11-cis-retinol production with an IC50 value of 232±3 nM[2]. |
|---|---|---|
| In Vivo | Emixustat (ACU4429) reduces the production of visual chromophore (11-cis retinal) in wild-type mice following a single oral dose (ED50=0.18mg/kg). In albino mice, emixustat is shown to be effective in preventing photoreceptor cell death caused by intense light exposure. Pre-treatment with a single dose of emixustat (0.3 mg/kg) provids a 50%protective effect against light-induced photoreceptor cell loss, while higher doses (1-3 mg/kg) are nearly 100%effective. In Abca4-/- mice, chronic (3 month) emixustat treatment markedly reduces lipofuscin autofluorescence and reduces A2E levels by 60%( ED50=0.47 mg/kg). In the retinopathy of prematurity rodent model, treatment with emixustat during the period of ischemia and reperfusion injury produces a 30%reduction in retinal neovascularization (ED50=0.46mg/kg)[1]. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7968 mL | 18.9840 mL | 37.9680 mL | 75.9359 mL |
| 5mM | 0.7594 mL | 3.7968 mL | 7.5936 mL | 15.1872 mL |
| 10mM | 0.3797 mL | 1.8984 mL | 3.7968 mL | 7.5936 mL |
| 20mM | 0.1898 mL | 0.9492 mL | 1.8984 mL | 3.7968 mL |
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