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Polyoxyl 15 hydroxystearate

This product is for research use only, not for human use. We do not sell to patients.

Polyoxyl 15 hydroxystearate
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
10g$553-6 Days
25g$853-6 Days
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Cat #: V38638 CAS #: 70142-34-6 Purity ≥ 98%

Description: Polyoxyl 15 hydroxystearate (Solutol HS 15; poly-oxyethylene esters of 12-hydroxystearic acid) is a novel non-ionic surfactant and emulsifier used as a solubilizer in formulation of compounds with low water solubility. Essentially, it is used to enhance the water/aqueous solubility of Class 2 and 4 [Biopharmaceutical Classification System (BCS)] lipophilic molecules. It can also increase the permeability of medium sized biological molecules/drugs across epithelia. Reference: Mechanism of mucosal permeability enhancement of CriticalSorb (Solutol HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27.

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CAS No.70142-34-6
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.