5-hydroxymethyl tolterodine (PNU 200577)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1040	Check With Us
250mg	$1800	Check With Us
500mg	$2700	Check With Us

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Cat #: V1168 CAS #: 207679-81-0 Purity ≥ 98%

Description: 5-hydroxymethyl tolterodine (Desfesoterodine, PNU 200577, PNU-200577, 5HMT, 5HM; 5-HMT, 5-HM), the active metabolite of tolterodine which is a medication used treat overactive bladder, is a novel and potent muscarinic receptor antagonist with a Kb of 0.84 nM.

References: Nilvebrant L, Gillberg PG, Sparf B. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81(4):169-72.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	341.49
Molecular Formula	C22H31NO2
CAS No.	207679-81-0
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 68 mg/mL (199.1 mM)rr
	Water: <1 mg/mLrr
	Ethanol: 68 mg/mL (199.1 mM)
SMILES Code	OC1=CC=C(CO)C=C1[C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C
Synonyms	Desfesoterodine, PNU-200577; 5-HMT, 5-HM; PNU200577; PNU 200577

Protocol	In Vitro	In vitro, Desfesoterodine preventes carbachol-induced contraction of guinea-pig isolated urinary bladder strips in a competitive and concentration-dependent manner
Protocol	In Vivo	In vitro, Desfesoterodine preventes carbachol-induced contraction of guinea-pig isolated urinary bladder strips in a competitive and concentration-dependent manner

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9283 mL	14.6417 mL	29.2834 mL	58.5669 mL
5mM	0.5857 mL	2.9283 mL	5.8567 mL	11.7134 mL
10mM	0.2928 mL	1.4642 mL	2.9283 mL	5.8567 mL
20mM	0.1464 mL	0.7321 mL	1.4642 mL	2.9283 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.