4EGI-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1060 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V1959 CAS #: 315706-13-9 Purity ≥ 98%
Description: 4EGI-1 is a potent and competitive eIF4E/eIF4G interaction inhibitor which binds to eIF4E with KD of 25 μM.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 451.28 |
|---|---|
| Molecular Formula | C18H12Cl2N4O4S |
| CAS No. | 315706-13-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 90 mg/mL (199.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Synonyms | 4EGI-1; 4-EGI1; 4 EGI 1; 4EGI1; 4EGI1; 4 EGI1; 4-EGI-1 |
| Protocol | In Vitro | 4EGI-1 is cytotoxic to breast cancer cells such as SKBR-3, MCF-7 and MDA-MB-231 cells, IC50 Approximately 30 μM for non-CSCs (cancer stem cells), IC50 Approximately 22 μM. 4EGI-1 enhances mammary CSC differentiation (40 μM) and inhibits breast CSC-induced HUVEC tubular structure formation (8 μM). In addition, 4EGI-1 selectively inhibits translations that persist in CSC maintenance and propagation. |
|---|---|---|
| In Vivo | 4EGI-1 (75 mg/kg, intraperitoneally) inhibits breast cancer stem cell (CSC) tumor growth and tumor angiogenesis in vivo |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2159 mL | 11.0796 mL | 22.1592 mL | 44.3184 mL |
| 5mM | 0.4432 mL | 2.2159 mL | 4.4318 mL | 8.8637 mL |
| 10mM | 0.2216 mL | 1.1080 mL | 2.2159 mL | 4.4318 mL |
| 20mM | 0.1108 mL | 0.5540 mL | 1.1080 mL | 2.2159 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.