4-iodo-SAHA
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $400 | Check With Us |
| 500mg | $650 | Check With Us |
| 1g | $975 | Check With Us |
: Cat #: V41465 CAS #: 1219807-87-0 Purity ≥ 99%
Description: 4-iodo-SAHA, a hydrophobic SAHA analog, is an HDAC1/6 inhibitor with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 390.22 |
|---|---|
| Molecular Formula | C14H19IN2O3 |
| CAS No. | 1219807-87-0 |
| Protocol | In Vitro | 4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines 4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells |
|---|---|---|
| In Vivo | 4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity | |
| Animal model | 8-week-old fvb mice | |
| Dosages | 50 mg/kg | |
| Administration | Oral gavage; 50 mg/kg five times per week; for 2 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5627 mL | 12.8133 mL | 25.6266 mL | 51.2531 mL |
| 5mM | 0.5125 mL | 2.5627 mL | 5.1253 mL | 10.2506 mL |
| 10mM | 0.2563 mL | 1.2813 mL | 2.5627 mL | 5.1253 mL |
| 20mM | 0.1281 mL | 0.6407 mL | 1.2813 mL | 2.5627 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.