This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 100mg | $1500 | In Stock |
| 250mg | $2500 | In Stock |
| 500mg | $3750 | In Stock |
: Cat #: V11588 CAS #: 2143542-28-1 Purity ≥ 98%
Description: 2BAct is a novel, potent, highly selective, CNS-permeable, and orally bioactive eif2b (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM, it prevents neurological defects caused by a chronic integrated stress response (ISR).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 440.80 |
|---|---|
| Molecular Formula | C19H16ClF3N4O3 |
| CAS No. | 2143542-28-1 |
| Protocol | In Vitro | Primary fibroblast lysates from R191H embryos had lower GEF activity than WT lysate, while 2BAct tripled this activity (EC).50=7.3 nM) |
|---|---|---|
| In Vivo | 2BAct (300 μg 2BAct/g meal; 21 weeks) normalize weight gain in VWM mice。 2BAct prevents motor deficits, myelin loss, and reactive glial hyperplasia in mice in VWM。 2BAct stimulates the residual activity of the mutant eIF2B complex in vivo, eliminating maladaptive stress responses |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2686 mL | 11.3430 mL | 22.6860 mL | 45.3721 mL |
| 5mM | 0.4537 mL | 2.2686 mL | 4.5372 mL | 9.0744 mL |
| 10mM | 0.2269 mL | 1.1343 mL | 2.2686 mL | 4.5372 mL |
| 20mM | 0.1134 mL | 0.5672 mL | 1.1343 mL | 2.2686 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.