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17-DMAG (Alvespimycin) HCl

This product is for research use only, not for human use. We do not sell to patients.

17-DMAG (Alvespimycin) HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$1200To Be Confirmed
2g$1900To Be Confirmed
5g$3205To Be Confirmed
email: [email protected]        [email protected]

Cat #: V0874 CAS #: 467214-21-7 Purity ≥ 98%

Description: 17-DMAG (Alvespimycin, NSC-707545, BMS-826476 HCl, KOS-1022) HCl, the hydrochloride salt of 17-DMAG, is a novel and potent HSP90 (heat shock protein 90) inhibitor with potential antineoplastic activity.

References: Ge J, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15.

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Molecular Weight (MW)653.21
Molecular FormulaC32H48N4O8•HCl
CAS No.467214-21-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 131 mg/mL (200.6 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
Solubility In Vivo1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
SMILES CodeNC(O[C@@H](/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC1=C2OCCN(C)C)[C@@H](OC)/C=CC=C(C)C(NC(C1=O)=CC2=O)=O)=O.[H]Cl
SynonymsAlvespimycin; Alvespimycin HCl; Alvespimycin Hydrochloride; NSC 707545; BMS 826476 HCl; KOS 1022; NSC-707545; BMS-826476 HCl; KOS-1022; NSC707545; BMS826476 HCl; KOS1022
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.5309 mL7.6545 mL15.3090 mL30.6180 mL
5mM0.3062 mL1.5309 mL3.0618 mL6.1236 mL
10mM0.1531 mL0.7655 mL1.5309 mL3.0618 mL
20mM0.0765 mL0.3827 mL0.7655 mL1.5309 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.