10058-F4
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $469 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V1587 CAS #: 403811-55-2 Purity ≥ 98%
Description: 10058-F4 (10058F4; 10058 F4) is a novel potent and selective c-Myc inhibitor with potential antineoplastic activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 249.35 |
|---|---|
| Molecular Formula | C12H11NOS2 |
| CAS No. | 403811-55-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 50 mg/mL (200.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 2% DMSO+Corn oil: 10 mg/mL |
| Synonyms | 10058-F4; 10058F4; 10058 F4 |
| Protocol | In Vitro | 10058-F4 inhibits the growth of leukemia cells and the dimerization of Myc and Max. 10058-F4 induces cell cycle arrest and apoptosis in AML cells. 10058-F4 blocks AML cells in the G0/G1 phase, downregulates c-Myc expression and upregulates CDK inhibitors p21 and p27. Meanwhile, 10058-F4 induces apoptosis by activating the mitochondrial pathway, manifested by downregulation of Bcl-2, upregulation of Bax, release of cytoplasmic cytochrome C, and lysis of caspase 3, 7, and 9. In addition, 10058-F4 induces bone marrow differentiation, possibly by activating multiple transcription factors. Similarly, 10058-F4-induced apoptosis and differentiation can be observed in primary AML cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.0104 mL | 20.0521 mL | 40.1043 mL | 80.2085 mL |
| 5mM | 0.8021 mL | 4.0104 mL | 8.0209 mL | 16.0417 mL |
| 10mM | 0.4010 mL | 2.0052 mL | 4.0104 mL | 8.0209 mL |
| 20mM | 0.2005 mL | 1.0026 mL | 2.0052 mL | 4.0104 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.